MersV1, Main, Exploration, bibRecord, 001527

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

Identifieur interne : 001527 ( Main/Exploration ); précédent : 001526; suivant : 001528

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

Auteurs : Jasper Fuk-Woo Chan ; Yanfeng Yao [République populaire de Chine] ; Man-Lung Yeung ; Wei Deng [République populaire de Chine] ; Linlin Bao [République populaire de Chine] ; Lilong Jia ; Fengdi Li [République populaire de Chine] ; Chong Xiao [République populaire de Chine] ; Hong Gao [République populaire de Chine] ; Pin Yu [République populaire de Chine] ; Jian-Piao Cai ; Hin Chu ; Jie Zhou ; Honglin Chen ; Chuan Qin [République populaire de Chine] ; Kwok-Yung Yuen

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2015.

RBID : PMC:7107395

Descripteurs français

KwdFr :
- Analyse de survie, Animaux, Antiviraux (administration et posologie), Callithrix, Charge virale, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Infections à coronavirus (anatomopathologie), Infections à coronavirus (traitement médicamenteux), Interféron bêta (administration et posologie), Lopinavir (administration et posologie), Modèles animaux de maladie humaine, Mâle, Repositionnement des médicaments, Ritonavir (administration et posologie), Résultat thérapeutique.
MESH :
- administration et posologie : Antiviraux, Interféron bêta, Lopinavir, Ritonavir.
- anatomopathologie : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- Analyse de survie, Animaux, Callithrix, Charge virale, Modèles animaux de maladie humaine, Mâle, Repositionnement des médicaments, Résultat thérapeutique.

English descriptors

KwdEn :
- Animals, Antiviral Agents (administration & dosage), Callithrix, Coronavirus Infections (drug therapy), Coronavirus Infections (pathology), Disease Models, Animal, Drug Repositioning, Interferon-beta (administration & dosage), Lopinavir (administration & dosage), Male, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Ritonavir (administration & dosage), Survival Analysis, Treatment Outcome, Viral Load.
MESH :
- chemical , administration & dosage : Antiviral Agents, Interferon-beta, Lopinavir, Ritonavir.
- drug therapy : Coronavirus Infections.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- pathology : Coronavirus Infections.
- Animals, Callithrix, Disease Models, Animal, Drug Repositioning, Male, Survival Analysis, Treatment Outcome, Viral Load.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe disease in human with an overall case-fatality rate of >35%. Effective antivirals are crucial for improving the clinical outcome of MERS. Although a number of repurposed drugs, convalescent-phase plasma, antiviral peptides, and neutralizing antibodies exhibit anti-MERS-CoV activity in vitro, most are not readily available or have not been evaluated in nonhuman primates. We assessed 3 repurposed drugs with potent in vitro anti-MERS-CoV activity (mycophenolate mofetil [MMF], lopinavir/ritonavir, and interferon-β1b) in common marmosets with severe disease resembling MERS in humans. The lopinavir/ritonavir-treated and interferon-β1b-treated animals had better outcome than the untreated animals, with improved clinical (mean clinical scores ↓50.9%–95.0% and ↓weight loss than the untreated animals), radiological (minimal pulmonary infiltrates), and pathological (mild bronchointerstitial pneumonia) findings, and lower mean viral loads in necropsied lung (↓0.59–1.06 log₁₀ copies/glyceraldehyde 3-phosphate dehydrogenase [GAPDH]; P < .050) and extrapulmonary (↓0.11–1.29 log₁₀ copies/GAPDH; P < .050 in kidney) tissues. In contrast, all MMF-treated animals developed severe and/or fatal disease with higher mean viral loads (↑0.15–0.54 log₁₀ copies/GAPDH) than the untreated animals. The mortality rate at 36 hours postinoculation was 67% (untreated and MMF-treated) versus 0–33% (lopinavir/ritonavir-treated and interferon-β1b-treated). Lopinavir/ritonavir and interferon-β1b alone or in combination should be evaluated in clinical trials. MMF alone may worsen MERS and should not be used.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107395

DOI: 10.1093/infdis/jiv392
PubMed: 26198719
PubMed Central: 7107395

Affiliations:

Le document en format XML

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<author><name sortKey="Xiao, Chong" sort="Xiao, Chong" uniqKey="Xiao C" first="Chong" last="Xiao">Chong Xiao</name>
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<author><name sortKey="Gao, Hong" sort="Gao, Hong" uniqKey="Gao H" first="Hong" last="Gao">Hong Gao</name>
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<author><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name>
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<author><name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name>
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<author><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name>
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<term>Antiviral Agents (administration & dosage)</term>
<term>Callithrix</term>
<term>Coronavirus Infections (drug therapy)</term>
<term>Coronavirus Infections (pathology)</term>
<term>Disease Models, Animal</term>
<term>Drug Repositioning</term>
<term>Interferon-beta (administration & dosage)</term>
<term>Lopinavir (administration & dosage)</term>
<term>Male</term>
<term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term>
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<term>Charge virale</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term>
<term>Infections à coronavirus (anatomopathologie)</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Interféron bêta (administration et posologie)</term>
<term>Lopinavir (administration et posologie)</term>
<term>Modèles animaux de maladie humaine</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term>
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<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Callithrix</term>
<term>Disease Models, Animal</term>
<term>Drug Repositioning</term>
<term>Male</term>
<term>Survival Analysis</term>
<term>Treatment Outcome</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de survie</term>
<term>Animaux</term>
<term>Callithrix</term>
<term>Charge virale</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Repositionnement des médicaments</term>
<term>Résultat thérapeutique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe disease in human with an overall case-fatality rate of >35%. Effective antivirals are crucial for improving the clinical outcome of MERS. Although a number of repurposed drugs, convalescent-phase plasma, antiviral peptides, and neutralizing antibodies exhibit anti-MERS-CoV activity in vitro, most are not readily available or have not been evaluated in nonhuman primates. We assessed 3 repurposed drugs with potent in vitro anti-MERS-CoV activity (mycophenolate mofetil [MMF], lopinavir/ritonavir, and interferon-β1b) in common marmosets with severe disease resembling MERS in humans. The lopinavir/ritonavir-treated and interferon-β1b-treated animals had better outcome than the untreated animals, with improved clinical (mean clinical scores ↓50.9%–95.0% and ↓weight loss than the untreated animals), radiological (minimal pulmonary infiltrates), and pathological (mild bronchointerstitial pneumonia) findings, and lower mean viral loads in necropsied lung (↓0.59–1.06 log<sub>10</sub>
 copies/glyceraldehyde 3-phosphate dehydrogenase [GAPDH]; <italic>P</italic>
 < .050) and extrapulmonary (↓0.11–1.29 log<sub>10</sub>
 copies/GAPDH; <italic>P</italic>
 < .050 in kidney) tissues. In contrast, all MMF-treated animals developed severe and/or fatal disease with higher mean viral loads (↑0.15–0.54 log<sub>10</sub>
 copies/GAPDH) than the untreated animals. The mortality rate at 36 hours postinoculation was 67% (untreated and MMF-treated) versus 0–33% (lopinavir/ritonavir-treated and interferon-β1b-treated). Lopinavir/ritonavir and interferon-β1b alone or in combination should be evaluated in clinical trials. MMF alone may worsen MERS and should not be used.</p>
</div>
</front>
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</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<settlement><li>Pékin</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name>
<name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name>
<name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name>
<name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name>
<name sortKey="Jia, Lilong" sort="Jia, Lilong" uniqKey="Jia L" first="Lilong" last="Jia">Lilong Jia</name>
<name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man-Lung" last="Yeung">Man-Lung Yeung</name>
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<name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name>
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<name sortKey="Yu, Pin" sort="Yu, Pin" uniqKey="Yu P" first="Pin" last="Yu">Pin Yu</name>
</country>
</tree>
</affiliations>
</record>

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EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001527 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001527 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:7107395
   |texte=   Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26198719" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

Serveur d'exploration MERS

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

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English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.